Background:: Paired-like homodomain transcription factor 3 has been found to be important for the differentiation and survival of midbrain dopaminergic neurons. Methods:: To determine whether genetic variation in the coding region of the paired-like homodomain transcription factor 3 gene plays a role in Parkinson's disease, genetic analysis was performed in 112 patients with Parkinson's disease. Results:: We did not identify any mutations except rs2281983, but when we extended the analysis of rs2281983 and 2 intron variants (rs4919621 and rs3758549) in 336 patients with Parkinson's disease and 244 controls, we found that rs2281983 and rs4919621 appeared to confer susceptibility to Parkinson's disease, especially in early-onset Parkinson's disease and familial Parkinson's disease. © 2011 Movement Disorder Society.
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Guo, Y., Le, W. D., Jankovic, J., Yang, H. R., Xu, H. B., Xie, W. J., … Deng, H. (2011). Systematic genetic analysis of the PITX3 gene in patients with Parkinson disease. Movement Disorders, 26(9), 1729–1732. https://doi.org/10.1002/mds.23693
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