Abstract
A rapid, duplex, high-resolution melting interleukin-28B gene (IL28B) genotyping assay, targeting both rs12979860 and rs8099917 polymorphisms, was developed and validated using 30 DNA samples from healthy volunteers. A linkage study on 300 healthy Singaporeans showed variable haplotypes. When the assay was applied to plasma DNA from 50 hepatitis C virus genotype-1 (HCV-1)-infected patients, five compound heterozygous types were detected. Copyright © 2012, American Society for Microbiology. All Rights Reserved.
Cite
CITATION STYLE
Poon, K. S., Ho, S. S. Y., Tang, J. W. T., Chua, C. W., Chiu, L., & Koay, E. S. C. (2012). Targeting both rs12979860 and rs8099917 polymorphisms with a single-tube high-resolution melting assay for IL28B genotyping. Journal of Clinical Microbiology, 50(10), 3353–3355. https://doi.org/10.1128/JCM.01718-12
Register to see more suggestions
Mendeley helps you to discover research relevant for your work.
