The targeted delivery of anti-inflammatory agents has great therapeutic potential for treating restenosis following percutaneous coronary intervention. To develop a drug delivery system targeted to injured blood vessels, we examined whether N-acetylglucosamine (GlcNAc)-bearing polymer-coated liposomes (GlcNAc-Ls) are specifically taken up by vascular smooth muscle cells (VSMCs). Flow cytometric analysis revealed that GlcNAc-Ls were taken up by VSMCs in vitro. Furthermore, GlcNAc-Ls were intravenously administered to mice that had undergone wire-mediated vascular injury. GlcNAc-Ls markedly accumulated at the intramural site of the injured vessel walls but not at the contralateral (uninjured) vessel walls. These results demonstrated that GlcNAc-Ls can be specifically taken up by VSMCs both in vitro and in vivo. We propose a novel strategy of using GlcNAc-Ls that has potential for application in drug delivery targeted to injured blood vessels. © 2011 The Japanese Society for Artificial Organs.
CITATION STYLE
Ise, M., Ise, H., Shiba, Y., Kobayashi, S., Goto, M., Takahashi, M., … Ikeda, U. (2011). Targeting N-acetylglucosamine-bearing polymer-coated liposomes to vascular smooth muscle cells. Journal of Artificial Organs, 14(4), 301–309. https://doi.org/10.1007/s10047-011-0595-3
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