Abstract
Variation in antidepressive medication response according to 5-HT2A genotype has been reported in several studies. Temperament has been proposed to be one of the vulnerability factors in mood and anxiety disorders. We studied temperament profiles of 98 patients with major depression and explored the interaction between Temperament and Character Inventory (TCI) temperament dimensions, 5-HT2A genotype (SNPs rs6311, rs6313 and rs7997012) and treatment response. No interactive effects for TCI temperament dimensions and 5-HT2A genotypes on antidepressive treatment response were found. 2010 Springer-Verlag.
Author supplied keywords
- *genotype
- *major depression/dt [Drug Therapy]
- *serotonin 2A receptor/ec [Endogenous Compound]
- *serotonin uptake inhibitor/dt [Drug Therapy]
- *temperament
- adult
- aged
- article
- citalopram/dt [Drug Therapy]
- controlled study
- female
- fluoxetine/dt [Drug Therapy]
- human
- major clinical study
- male
- paroxetine/dt [Drug Therapy]
- priority journal
- single nucleotide polymorphism
- treatment response
Cite
CITATION STYLE
K., A., O., K., E., S.-S., M., V., O., P., T., N., … A., I. (2010). Temperament profiles, 5-HT2A genotype, and response to treatment with SSRIs in major depression. Journal of Neural Transmission. K. Andre, Medical School, University of Tampere, Tampere 33014, Finland. E-mail: kadriandre@hot.ee: Springer Wien (Sachsenplatz 4-6, P.O. Box 89, Vienna A-1201, Austria). Retrieved from http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=reference&D=emed9&NEWS=N&AN=2011022830
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