The volatile oil of Nigella sativa seeds was prominent in in vitro anti- shigella activity against eight multiple drug resistant strains of Shigella flexneri. The anti-shigella activity against Shigella flexneri Y SH-4 was observed in the sera of monkeys after 45-60 min of oral administration of the oil. It exhibited promising in vivo anti-shigella activity against the same strain when tested in monkey models with experimental shigellosis, fully curing the infected monkeys within 3 days. The rectal swabs of the experimental groups became free of the challenge organism on day 3 of treatment with the volatile oil.
CITATION STYLE
Azad Chowdhury, A. K., Islam, M. A., Rashid, M. A., & Ferdous, A. J. (1998). Therapeutic potential of the volatile oil of Nigella sativa seeds in monkey model with experimental shigellosis. Phytotherapy Research, 12(5), 361–363. https://doi.org/10.1002/(SICI)1099-1573(199808)12:5<361::AID-PTR302>3.0.CO;2-1
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