Primaquine is currently the only drug available for radical cure of Plasmodium vivax and P. ovale liver infection stages, but limited safety data exist for children <10 years of age. Detailed daily assessments of side effects in glucose-6-phosphate dehydrogenase (G6PD)-normal children treated with 14 days of primaquine plus chloroquine (3 days; n = 252) or artesunate (7 days; n = 141) (0.5 mg/kg of body weight) showed that both treatments are well tolerated, do not lead to reductions in hemoglobin levels, and can thus safely be used in children 1 to 10 years of age. Copyright © 2012, American Society for Microbiology. All Rights Reserved.
CITATION STYLE
Betuela, I., Bassat, Q., Kiniboro, B., Robinson, L. J., Rosanas-Urgell, A., Stanisic, D., … Mueller, I. (2012). Tolerability and safety of primaquine in Papua New Guinean children 1 to 10 years of age. Antimicrobial Agents and Chemotherapy, 56(4), 2146–2149. https://doi.org/10.1128/AAC.05566-11
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