Treatment of intraocular spread of acanthamoeba after tectonic corneal graft in acanthamoeba keratitis

Abstract

The number of reports on anterior chamber detection of Acanthamoeba by PCR in the course of Acanthamoeba keratitis (AK) has risen, frequently following recent tectonic keratoplasty [1-3]. Topical biguanide or diamidines do not enter the AC [4] and are cytotoxic when used intraocularly. Herein we report the use of intracameral voriconazole, with proven cysticidal activity in AK [5, 6], for intraocular dissemination of Acanthamoeba, in two consecutive patients.