Tumor necrosis factor alpha gene variants do not display allelic imbalance in circulating myeloid cells

  • S. W
  • K. K
  • K. B
  • et al.
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Abstract

Carriage of the TNF -308 A allele (rs1800629 A) has been associated with increased serum TNF-alpha levels, the development of sepsis syndrome, and fatal outcome, in severely traumatized patients (Menges et al., 2008 [1]). Herein, we analysed the putative allelic imbalance of TNF-alpha release from myeloid cells. Circulating peripheral blood cells from healthy human blood donors (n=104) and monocyte-derived macrophages (n=158) were analysed for their ex vivo capacity of TNF-alpha expression. Our findings indicate that carriage of the TNF -308 A allele is not associated with high TNF-alpha expression in circulating human leucocytes and monocyte-derived macrophages. Other cellular sources, e.g. tissue-resident cells like mast cells and/or tissue specific macrophages might be the cellular source of high TNF-alpha serum levels shortly after trauma. © 2010 Elsevier Inc.

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S., W., K., K., K., B., C., L., A., N., & H., H. (2010). Tumor necrosis factor alpha gene variants do not display allelic imbalance in circulating myeloid cells. Cellular Immunology. S. Wienzek, Institute for Clinical Immunology and Transfusion Medicine, Justus-Liebig-University Giessen, Langhansstrasse 7, D 35392 Giessen, Germany. E-mail: Sandra.Wienzek@immunologie.med.uni-giessen.de: Academic Press Inc. (6277 Sea Harbor Drive, Orlando FL 32887-4900, United States). Retrieved from http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=reference&D=emed9&NEWS=N&AN=2010222960

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