Uncoupling of longevity and telomere length in C, elegans

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Abstract

The rsematode Caenorfoabditis eiegans, after completing its deveiopmenta! stages and a brief reproductive period, spends the remainder of its adyut life as an organism consisting exckssiveSy of post-mitotic ceias, Here we show that tefomere length varies considerably in ciona! populations of wild-type worms, and that these length differences are conserved over at ieast ten generationSj suggesting a length regulation mechanism in ds, This observation is strengthened by the finding that the bulk teaomere length in different worm strains varies considerably, Despite the dose correction of teSamere length and clanai ceuuiar senescence in mammaliar? celis, nematodes with Song teSomeres were neither fortg livedf nor did worm popyiatiorss with comparabiy short teiomeres exhibit a shorter !ife spars, Conversely, iong-Hved daf-2 arsd short-Hved daf-16 mutant animais cars have either iong or short teSomeres, Tefomere fength of post-mstotk cells did not change during the aging process, and the response of animais to stress was found independent of teiomere iength, Couectiveiy, oyr data indicate that tefomere length and life span can be imcoypled in a post-mstotic setting, suggesting separate pathways for replication-dependent and -independent aging. Copyright: © 2005 Raices et, al.

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APA

Raices, M., Maruyama, H., Dillin, A., & Kariseder, J. (2005). Uncoupling of longevity and telomere length in C, elegans. PLoS Genetics, 1(3), 295–301. https://doi.org/10.1371/journal.pgen.0010030

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