Purpose: Kinesin-mediated cargo vesicle transport is fundamental to the maintenance of a proper lens fiber structure, which is essential for the transparency of the lens. Here, we test the hypothesis that the rs8702 polymorphism in the kinesin light chain 1 gene (KLC1), previously linked to Alzheimer disease (AD), may play a role in cataractogenesis. Methods: Patients with nuclear (n=76), cortical (n=154), posterior subcapsular (n=117), and mixed (n=148) cataract as well as 183 controls were analyzed for the KLC1 rs8702 polymorphism using the dynamic allele-specific hybridization (DASH) technique. Results: The GG genotype of rs8702 was significantly over-represented among cataract patients as compared to controls (63% versus 52%, respectively, p=0.008) and associated with an age-adjusted odds ratio for cataract development of 1.61 (95% confidence interval 1.12-2.31). This association was not confined to any particular cataract type. Conclusions: The KLC1 gene may be a novel susceptibility gene for age-related cataract. © 2007 Molecular Vision.
CITATION STYLE
Andersson, M. E., Zetterberg, M., Tasa, G., Seibt-Palmér, M., Juronen, E., Teesalu, P., … Zetterberg, H. (2007). Variability in the kinesin light chain 1 gene may influence risk of age-related cataract. Molecular Vision, 13, 993–996.
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