Variants in FAM13A are associated with chronic obstructive pulmonary disease

Abstract

We performed a genome-wide association study for chronic obstructive pulmonary disease (COPD) in three population cohorts, including 2,940 cases and 1,380 controls who were current or former smokers with normal lung function. We identified a new susceptibility locus at 4q22.1 in FAM13A and replicated this association in one case-control group (n = 1,006) and two family-based cohorts (n = 3,808) (rs7671167, combined P = 1.2 × 10 11, combined odds ratio in case-control studies 0.76, 95% confidence interval 0.69-0.83). © 2010 Nature America, Inc. All rights reserved.