High doses of orally administered vitamin E (1000 IU/day) have been given to ten normal volunteers. Ten control subjects received placebo. Red blood cell glutathione was significantly higher in treated subjects than in the controls (controls: 267.5 ± 15.7 μg/mL; treated: 374.8 ± 17.3 μg/mL). These findings could be explained by an increase of glutathione synthesis brought about by the stimulation of glutathione synthetase activity. An alternative possibility is a reduced utilization of glutathione for the detoxification of free radicals. These two mechanisms could be effective in counteracting the glutathione content feedback of the synthetizing enzymes. © 1985.
CITATION STYLE
Costagliola, C., Libondi, T., Menzione, M., Rinaldi, E., & Auricchio, G. (1985). Vitamin E and red blood cell glutathione. Metabolism, 34(8), 712–714. https://doi.org/10.1016/0026-0495(85)90019-8
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