Senior Scientist (Discovery Safety, DSM)

England, Cambridgeshire
Oct 05, 2017
Nov 04, 2017
AstraZeneca UK
Contract Type
Full Time

Position: Senior Scientist (Discovery Safety, DSM)

Location: Cambridge, UK

Salary: Competitive & Excellent Benefits Package

At AstraZeneca we win through science, it is at the heart of our every success. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality. We make the most of your skills and passion by actively supporting you to see what you can achieve no matter where you start with us.

As a Senior Scientist within Discovery Safety you will play a pivotal role in overcoming major challenges in the discovery of innovative medicines: ensuring they are safe enough to provide novel treatments for patients. In Discovery Safety, a global department that is part of our Drug Safety and Metabolism function, we apply innovative science to drive the design and selection of safer medicines. As true Drug Hunting partners to our Innovative Medicines units, we contribute to the selection of novel drug targets, design of therapeutic concepts, identification and optimization of new chemical series as well as a range of other modalities, and selection of novel candidate drugs. We develop and apply cutting edge in silico, molecular, cellular technologies and push the boundaries of predictive safety science with our mission in mind: driving our science to bring better, safer medicines to patients sooner.

In Drug Safety and Metabolism, we place a strong emphasis on talent development. You will be able to develop your scientific leadership by working together with leaders in, investigative toxicology, drug discovery, cell biology and predictive safety science.

Bring your scientific excellence to our Senior Scientist position and become a key player in the discovery of innovative medicines.

Main Duties and Responsibilities

As a Senior Scientist, you will be working closely with Discovery colleagues towards the development of in-depth, molecular safety endpoints.

You will design and execute in-vitro experimental strategies to predict, assess and mitigate target- and drug-related safety risks in discovery programs for our Oncology and Neuroscience IMEDs. You will translate theoretical drug target safety assessments into concrete experimental plans and action, and drive the development of molecular and cellular mechanistic understanding of toxicological aspects and safety concerns around innovative drug discovery projects. In addition, you will integrate novel in-vitro safety assays and technologies to drive our predictive toxicology scientific capabilities forward.


  • Excellent scientist, with a PhD in cell biology, toxicology, pharmacology, systems biology or related field, and evidence of a strong scientific track record and problem-solving capabilities.
  • Theoretical and practical knowledge of, and experience with, techniques and technologies relevant to in vitro systems, including cell culture and cell-based assay systems utilising cell lines and primary cells (examples could include high content screening, -omics technologies, advanced cell systems, gene editing, microphysiological systems).
  • Extensive experience in experimental design, generation and interpretation of high quality experimental data and translating scientific findings into applicable information.
  • Strong communication and presentation skills and the ability to work across multi-disciplinary teams.
  • Highly motivated, creative, innovative, reliable scientist, with a flexible, collaborative, team-oriented mindset, who solves problems in a goal-focused fashion and is keen to create impact.
  • A social personality that contributes to an open, positive, collaborative working climate, and a strong desire to drive personal development.


  • Scientific knowledge of bone marrow biology and hematopoiesis.
  • Understanding of the drug discovery process from experience in the pharmaceutical industry.
  • Experience with design and execution of in vitro experiments to determine the effects of therapeutics on biological systems, including data analysis.
  • Knowledge of predictive toxicology, safety and risk assessment.

Applications Open: 5th October 2017

Applications Close: 5th November 2017