Senior Scientist (Discovery Safety, DSM).

England, Cambridgeshire
Oct 05, 2017
Nov 04, 2017
AstraZeneca UK
Contract Type
Full Time
Job Type
Senior Scientist

Position: Senior Scientist (Discovery Safety, DSM).

Location: Cambridge Science Park.

Salary: Competitive with excellent benefits.

At AstraZeneca we win through science, it's at the heart of our every success. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality. We make the most of your skills and passion by actively supporting you to see what you can achieve no matter where you start with us.

As a Senior Scientist within Discovery Safety you will play a pivotal role in overcoming major challenges in the discovery of innovative medicines: ensuring they are safe enough to provide novel treatments for patients. In Discovery Safety, a global department that is part of our Drug Safety and Metabolism function, we apply innovative science to drive the design and selection of safer medicines. As true Drug Hunting partners to our Innovative Medicines units, we contribute to the selection of novel drug targets, design of therapeutic concepts, identification and optimization of new chemical series as well as a range of other modalities, and selection of novel candidate drugs. We develop and apply cutting edge in silico, molecular, cellular technologies and push the boundaries of predictive safety science with our mission in mind: driving our science to bring better, safer medicines to patients sooner.

In Drug Safety and Metabolism, we place a strong emphasis on talent development. You will be able to develop your scientific leadership by working together with leaders in, investigative toxicology, drug discovery, cell biology and predictive safety science.

Bring your scientific excellence to our Senior Scientist position and become a key player in the discovery of innovative medicines.

Main Duties and Responsibilities
As a Senior Scientist you will be working closely with Discovery Safety and Genetic Toxicology colleagues towards the development of in-depth, molecular safety endpoints.

Develop a strong understanding of target related safety risks for both small and large molecule development in all AZ IMED areas. You will design and execute experimental strategies to predict, assess and mitigate target- and drug-related safety risks, and drive the development of molecular and cellular mechanistic understanding of safety aspects for a variety of projects.

Essential Requirements

  • A PhD in a toxicology/pharmacology/ molecular biology related field with experience of a sequencing, NGS, and evidence of a strong scientific track record and problem-solving capabilities.
  • Highly motivated, creative, innovative, reliable scientist, with a flexible and collaborative team-oriented mind-set, who solves problems in a goal-focused fashion and is keen to create impact.
  • The ability to build an understanding of biology around novel targets and pathways, develop testable hypotheses and drive scientific learning.
  • Experience in experimental design, generation and interpretation of high quality experimental data and translating scientific findings.
  • Excellent communication and presentation skills and the ability to work across multi-disciplinary teams with a good publication record.
  • A social personality that contributes to an open, positive, collaborative working climate, and a strong desire to drive personal development.

Desired Requirements

  • Appreciation and understanding of techniques and technologies relevant to in vitro systems, including cell culture and cell-based assay systems utilising cell lines and primary cells (examples could include high content screening, -omics technologies, advanced cell systems, gene editing, microphysiological systems).
  • Understanding of the drug discovery process from experience in the biotech/pharmaceutical industry.
  • Experience with design and execution of in-vitro and in-vivo experiments to determine the effects of therapeutics on biological systems, including data analysis.
  • Knowledge of predictive toxicology, safety and risk assessment.

If you are interested, apply now!
To be considered for this exciting opportunity, please complete the full application on our website at your earliest convenience - it is the only way that our Recruiter and Hiring Manager can know that you feel well qualified for this opportunity. If you know someone who would be a great fit, please share this posting with them. This post is based in Cambridge in the UK.

AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law. AstraZeneca only employs individuals with the right to work in the country/ies where the role is advertised.

Opening date: 2nd October 2017

Closing date: 2nd November 2017