Postdoctoral scholarship in translational biomedical technology – polymer microencapsulation of ther

Location
Stockholm (SE)
Salary
generous remuneration in the form of a scholarship
Posted
Nov 04, 2017
Closes
Jan 04, 2018
Contract Type
Full Time
Job Type
Postdoc

https://www.kth.se/en/om/work-at-kth/stipendier/postdoctoral-scholarship-in-translational-biomedical-technology-polymer-microencapsulation-of-therapeutic-cells-1.770306

 

KTH Royal Institute of Technology in Stockholm has grown to become one of Europe’s leading technical and engineering universities, as well as a key centre of intellectual talent and innovation. We are Sweden’s largest technical research and learning institution and home to students, researchers and faculty from around the world. Our research and education covers a wide area including natural sciences and all branches of engineering, as well as in architecture, industrial management, urban planning, history and philosophy.

Workplace

Become a part of world-leading research and education! The School of Electrical Engineering is one of ten schools at KTH. We conduct research and education in Electrical Engineering, Systems Engineering, Information Technology, Space, Fusion and Plasma Physics. The field of electrical and electronic engineering at KTH is internationally recognized and places high in international rankings. The school is responsible for bachelor and master programs in Electrical Engineering which are closely linked to our research fields. 450 people work together in an international environment in eight departments and in the Dean’s office.

This position is for collaboration between the KTH Department of Micro and Nanosystems and the Karolinska Institute Department of Clinical Science, Intervention and Technology

The work will be carried out at KTH Department of Micro and Nano systems, which is one out of eight departments in the School of Electrical Engineering, and amongst the world’s leading academic groups in this field. The department staff consists of fifty faculty members, researchers and PhD students who contribute to a high professional standard of intensive work and quality results, as well as to a friendly and open environment. The staff has a multicultural background and the working language is English. The department is internationally well established, has many research collaborations with excellent partners worldwide, and is involved in several European and national projects.

The responsible PI at KTH is Professor Wouter van der Wijngaart: www.kth.se/profile/wouter

Karolinska Institutet is one of the world’s leading medical universities, ranked 7th worldwide and 3rd in Europe according to the QS World University Rankings by Subject 2017. Its vision is to significantly contribute to the improvement of human health. Karolinska Institutet accounts for the single largest share of all academic medical research conducted in Sweden and offers the country’s broadest range of education in medicine and health sciences. The Nobel Assembly at Karolinska Institutet selects the Nobel laureates in Physiology or Medicine.
Karolinska Institutet strives to provide a workplace that has approximately the same number of women and men, is free of discrimination and offers equal opportunity to everyone.

The responsible PI at KI is Professor Matthias Löhr: ki.se/en/people/matloh

Project description

Background:

Inoperable malignant tumours are treated with radiation and systemic chemotherapy, both treatments leading to a high prevalence of co-morbidity. Our aim is to enable localised chemotherapy to allow for a higher toxic drug concentration at the tumour site, while excusing the rest of the body from toxicity. For this purpose, we have developed a precisely controlled polymer encapsulation of therapeutic cells prior to their implantation into a tumour. The therapeutic cells are genetically modified to convert a mild systemic drug into a high toxic compound that acts locally at the implantation site. The cell capsules are fabricated using a droplet microfluidic system. We developed a novel polymerization scheme to produce microscale cell capsules with a well-controlled core-shell structure of diameter 100 micrometer, and demonstrated the successful encapsulation of living cells (unpublished results).

Aim of the project:

The postdoc is expected to progress the project from its current state to successful pharmacological testing of the microcapsules in-vitro and in-vivo. This work will include: the maintenance of a cell line of genetcally modified cells; the polymer encapsulation of the genetically modified cells; the in-vitro pharmaceutical testing of the encapsulated cells; and the in-vivo testing in animal models.

Remuneration:

KTH offers an attractive working environment and generous remuneration in the form of a scholarship. As a postdoctoral scholar you have many opportunities to participate at conferences, projects and other relevant events, which will extend your professional network and benefit your future career.

Qualifications

Candidates should have a Ph.D. or be near Ph.D. defense. The background of the candidate is preferably biomedical engineering or similar. The candidate will be the main person driving this project and will be expected to take a de-facto lead in the project.

We are looking for a strongly motivated person, who is able to work independently. Good command of English orally and in writing is required to present and publish research results. The applicant preferably has an outstanding research and publication record.

The candidate will be selected based on her/his excellence and her/his skills. Beyond the above listed general skills, the candidate is expected to possess the following specific skills:

Skills of highest importance:

  • Having the capability to work as an independent researcher
  • Having well-developed analytical and problem solving skills
  • Having experience in working with cells/cell cultures

Skills of high importance:

  • Experience in polymer engineering
  • Experience in microfluidic systems technology

Skills of importance:

  • Experience with animal models

Application

Apply to this scholarship by e-mail to rekrytering@ee.kth.se

Application deadline: Your complete application must be received at KTH no later than January 7, 2018.

Mark your application with reference number E-2017-1213 in the e-mail subject field.

You are responsible for ensuring that your application is complete according to the instructions below.

The application must include:

  • CV including your relevant professional experience and knowledge.
  • Copy of the degree certificate(s) and transcripts of records from your previously attended university-level institutions. Translations into English or Swedish if the original documents are not issued in one of these languages.
  • Statement of purpose: what are your future interests, and how do you envision the current position to help you in reaching those. In other words: what do you expect from this position and how would you organize your work to reach your expectations? (maximum 2 pages long)
  • A list and short discussion of your main personal strenghts and weaknesses. (maximum 2 pages long)
  • Representative publications or technical reports: For documents that are available online, please provide the DOI. Other documents no longer than 10 pages each, please attach. For longer documents (e.g. theses), please provide a summary (abstract) and a web link to the full text.
  • Letters of recommendation.
  • Contact information for two reference persons. We reserve the right to contact references only for shortlisted candidates.

Please observe that you apply for a scholarship, not an employment.

About the scholarship

Period: Initially 1 year with possible extension with 1 more years.

Extent:Full-time

Access: According to agreement, preferably as soon as possible

Number of positions: 1

City: Stockholm

Contact:

  1. Wouter van der Wijngaart, Professor, wouter@kth.se , +46 (0)8 790 66 13
  2. Mikael Visén, HR administrator, rekrytering@ee.kth.se, + 46 (0)8 790 84 89

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