Bioinformatician - Genomics

Location
Newcastle, GB
Salary
£28,331.00 - £32,817.00
Posted
Jun 18, 2020
Closes
Jul 18, 2020
Ref
4745
Contract Type
Full Time
Job Type
Developer
We are a world class research-intensive university. We deliver teaching and learning of the highest quality. We play a leading role in economic, social and cultural development of the North East of England. Attracting and retaining high-calibre people is fundamental to our continued success.

Salary: £28,331.00 - £32,817.00
Closing Date: 18 July 2020

The Role

We are looking for a dynamic individual with a strong background in bioinformatics to join our world-leading research team at the WCMR (http://www.newcastle-mitochondria.com), working with colleagues across the WCMR who have an international reputation for their expertise in understanding the health-related outcomes of mitochondrial disease, associated disease mechanisms and development of novel therapies.

The principal purpose of this role is to provide bioinformatics leadership and support within the Wellcome Centre for Mitochondrial Research (WCMR) at Newcastle University. You will coordinate and support informatics analysis across a broad portfolio of research projects across the WCMR, working closely with principal investigators, post-doctoral scientists and graduate students. In this context, you will develop and maintain novel analytical pipelines for multidimensional datasets, including whole exome and genome sequencing, RNA sequencing, proteomic and metabolomic data from patient-derived pathological samples and experimental models, with the ultimate goal of improving our understanding of mitochondrial biology and disease mechanisms and contributing to work aimed at developing novel therapies.

You will also be involved in the training and supervision of PhD students and junior WCMR members in the application of bioinformatics tools and will be encouraged and mentored to develop their own, independent research areas which align with the WCMR's vision.

Ideal candidates should have a proven track record (evidenced by publications and/or experience in a previous role) and show an enthusiasm and intellectual curiosity to apply a broad range of bioinformatics tools and pipelines to understanding mitochondrial disease progression and complexity.

This post provides an exciting opportunity for an individual with bioinformatics expertise. Candidates should attach a statement to their application that describes their research interests and, in particular, highlights their relevant experience. You will work closely with Professor Rob Taylor (robert.taylor@newcastle.ac.uk) and Dr Gavin Hudson (gavin.hudson@ncl.ac.uk), to whom informal enquiries can be made, and the Faculty Bioinformatics Support Unit (BSU).

This is a full time, fixed term post available until 30th April 2022.

Key Accountabilities
  • To develop, enhance and participate in cutting edge genetics related research across the WMCR. This will involve assisting with the initial design of research project protocols, subsequent analysis and the interpretation of informatic outputs. This will also involve collaboration with both the Biosciences and Translation and Clinical Translational Research Institutes, and Bioinformatic Support Unit.
  • You will be encouraged and mentored to develop their own, independent research areas which align with the WCMR's strategies, vision and team working.
  • To develop and maintain novel computational pipelines for the analysis of next-generation sequencing data (genomic, transcriptomic and epigenetic) and high-dimensional proteomic data (deep phenotyping) derived from cutting-edge WCMR projects.
  • To provide support and informatic guidance for the bioinformatic analysis of publicly available 'omics' datasets (i.e. Genomics England and UKBiobank) and to assist in the development of research projects using this data.
  • Provide bioinformatics advice, training and guidance to a wide range of WCMR affiliated research staff and students as required (e.g. advising on experimental design and the validation of results etc.). This will also involve, assisting PIs develop grant proposals for research bids, contributing to writing technical reports and contributing to research papers for publication.
  • Regularly appraise and test new software to ensure that the sequencing and proteomic data analysis, annotation and interpretation pipelines are up-dated effectively.
  • Maintain a high level of up-to-date specialist knowledge of bioinformatics, by reading relevant journals and participating in relevant conferences, to support WCMR in making strategic decisions on computational infrastructure purchases and upgrades.
  • Liaise with local IT department to effectively adapt hardware to meet WCMR demands - processing power and data storage etc. and safeguard the reliability and validity of data at all stages of analysis using appropriate quality control and version control procedures and the practice of reproducible research.
  • Disseminate relevant information within the WCMR team, locally through internal seminars, and nationally.
  • Any other duties within the remit of the grade as required by the Head of Academic Unit.

The Person (Essential)

Knowledge, Skills and Experience
  • Experience working as a bioinformatician in a research setting.
  • Experience working with a Unix/Linux HPC computing environment, with experience in relevant programming languages (i.e. Python etc).
  • Experience accessing and utilising external, publicly available datasets (i.e. Genomics England, UKBioBank and EBI).
  • Experience analysing, visualising and annotating high-throughput sequencing or proteomics data and disseminating this data to non-informatic researchers.
  • An in-depth specialist understanding of the informatics field, with an interest in the evaluation and adoption of the latest bioinformatics and computational biology methodologies, complemented by a grounded, theoretical, knowledge of genetic, cell and molecular biology.
Desirable
  • Evidence of contributing to successful applications for national/international peer reviewed research funding.
  • Evidence of completed research and publications in peer reviewed journals.
  • Experience in the design and analysis and delivery of research projects.
  • Experience with a programming language for application development.
  • Proficiency using statistical packages (i.e. R).
  • Experience working with large volume data sets (e.g. differential gene expression, exome or genome sequencing).
  • Direct experience of single cell transcriptomic, epigenetic, proteomic and genomic datasets.
  • Direct experience of high dimensional flow cytometry data set analysis.
  • Knowledge of SQL databases, web development.
  • Knowledge of LIMS design and implementation.
Attributes and Behaviour
  • Excellent interpersonal and communication skills (both written and oral) to be able to work alongside individuals with different levels of technical knowledge.
  • Keep up to date with new / improved bioinformatics knowledge, skills, techniques and research.
  • High level of self-motivation and initiative.
  • Excellent organisational skills.
  • Strong team player.
  • Creative problem solving.
  • Strong attention to detail.
  • Ability to work flexibly.
  • Ability and willingness to travel locally, within UK and internationally for meetings and conferences
Desirable
  • Knowledge and understanding of the regulatory framework and good research practice underpinning research.
  • Understanding of health and safety regulations and procedures within a higher education environment.
  • Outline understanding of UK research funding procedures.

Qualifications
  • A PhD in a relevant area is essential.
 
Newcastle University is committed to being a fully inclusive Global University which actively recruits, supports and retains staff from all sectors of society.  We value diversity as well as celebrate, support and thrive on the contributions of all our employees and the communities they represent.  We are proud to be an equal opportunities employer and encourage applications from everybody, regardless of race, sex, ethnicity, religion, nationality, sexual orientation, age, disability, gender identity, marital status/civil partnership, pregnancy and maternity, as well as being open to flexible working practices.
 
The University holds a silver Athena SWAN award in recognition of our good employment practices for the advancement of gender equality.  The University also holds the HR Excellence in Research award for our work to support the career development of our researchers, and is a member of the Euraxess initiative supporting researchers in Europe.
 
Requisition ID: 4745