Cancer Bioinformatician - London

London, England
Mar 19, 2018
Apr 18, 2018
Contract Type
Full Time
Job Type

Senior Cancer Analyst - Genomics

Paramount are working in partnership with Genomics England to expand their team in order to deliver success with the 100,000 Genomes Project. This is a challenging and fast moving project with the aim to carry out whole genome sequencing on 100,000 participants. Genomics England works with key partners to collect, transport, store, quality check and sequence the samples from participants. The aim for this project is to create a new genomic medicine service for the NHS - transforming the way people are cared for. Patients may be offered a diagnosis where there wasn't one before. In time, there is the potential of new and more effective treatments.
Genomics England applies state of the art approaches to whole genome sequences for processing, analysis, quality assurance and annotation. This includes integrating phenotypic and other clinical data with whole genome sequencing to create a world-leading, high fidelity data repository for the NHS and third party users.
The Bioinformatics team develops and applies state of the art approaches to 100,000 whole genome sequences (WGS) in the areas of:
*Analysis of WGS in cancer and rare diseases
*Sequence alignment and variant calling of up to 100 genomes per day
*Quality assurance and sample provenance monitoring
This senior level analyst role is part of a highly motivated Bioinformatics team, working as part of a small team responsible for cancer analysis.
*Monitoring quality of WGS data
*Benchmarking tools for cancer WGS analysis
*Performing computational analyses for a range of projects
*Developing and implementing new features for cancer sequencing data analysis
*Establishing general bioinformatics resources for day-to-day use by colleagues
*MSc or PhD (or equivalent experience) in Bioinformatics or Cancer Molecular Biology or equivalent work experience
*Good knowledge of cancer genomics
*Solid skillset in Bioinformatics and experience of working as a computational biologist
*Practical knowledge of NGS algorithms and available resources for cancer bioinformatics
*Experience with full cycle of analysing NGS data from sequencing QC to annotation and prioritization of variants
*Experience with handling large data sets and setting pipelines
*Strong programming skills (Python, R); ability to develop codes as a part of team
*Practical knowledge and understanding of statistics
*Excellent technical writing skills
*A demonstrable ability to cope under pressure and deliver to deadlines
*Ability to communicate effectively within a multidisciplinary team
*Flexible and co-operative approach to colleagues
*Ability to work independently and to show initiative within a team
*Ability to prioritise and balance competing demands

There are some great benefits on offer with this role including a competitive salary, pension, generous holidays and more.
Please do not hesitate to contact Harvey Uppal at or call (+44) 121 616 3407 to discuss this opportunity further.
Keywords: Bioinformatics, Genomics, London, WGS, WES, Cancer, NGS, Molecular, Biology, Computational, QA, QC, Analyst, Python, R, Statistics, Pipeline

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