Scientist I

Cambridge, MA, USA
Aug 04, 2018
Sep 01, 2018
Contract Type
Full Time
Job Type
Senior Scientist
46591BRAuto req ID:46591BRJob Code:RS0158 Scientist I Location:USA - MA - Boston Business Title:Staff Scientist - Organ Chip-Enabled Therapeutic DiscoverySub-Unit:Wyss Institute Salary Grade:058Time Status:Full-time Union:00 - Non Union, Exempt or Temporary Basic Qualifications:PhD in Cell Biology, Pharmacology, Physiology or related field with more than 3 years of experience in in vitro cell-based assays, cell and organ physiology, pharmacology or related areas. Industry experience required. Additional Qualifications:Experience in the pharmaceutical/biotech industry strongly preferred. Expertise in culturing and assaying primary and human iPS-derived cells is a plus, and knowledge of drug metabolism and pharmacokinetics (DMPK) would be valuable as well. Demonstrated industrial experience in drug development using cell culture techniques and cell-based screening assays with primary cells or established cell lines for DMPK and pharmacodynamics (PD), as well as establishment of assays for drug efficacy or toxicity in conventional culture models and/or microfluidic formats would be an advantage. Experience with cell isolation, cryopreservation techniques, and both toxicity and efficacy assays is also preferred.

The candidate should have strong organizational and communication skills required to assist and collaborate with a multidisciplinary group of technology innovators and engineers, as well as biologists and clinicians, in a dynamic team environment. An ability to tackle multiple projects simultaneously as a member of an integrated multidisciplinary team is essential. Extensive knowledge of the drug discovery and development process and experience mentoring fellows and/or students is preferred. Proficiency with personal computers and applicable software packages (Microsoft Word, Excel) is crucial.

Additional Information:This is a term position for two years with the strong possibility of renewal.Department:Wyss InstitutePre-Employment Screening:Education, IdentityJob Function:Research Duties & Responsibilities:The mission of the Wyss Institute for Biologically Inspired Engineering at Harvard University is to transform human healthcare and the environment by emulating the way nature builds. Developed as an alliance between Harvard and other premier academic and clinical partner institutions, Institute faculty and staffcollaborate in high-risk scientific research and technology development. A major focus of the Institute is to translate thetechnologies developed by its faculty and staffinto commercial products and therapies through collaborations with clinical investigators and establishment of corporate alliances or new startups. For more information, visit:

The Wyss Institute for Biologically Inspired Engineering at Harvard University seeks a talented, enthusiastic and experienced individual to work as an Advanced Technology Team Staff Scientist on the Bioinspired Therapeutics and Diagnostics platform. The successful candidate for thisposition will report to the Lead Senior Staff Scientist and Faculty Leader of the Bioinspired Therapeutics & Diagnostics Platform. The candidate should have a strong and broad knowledge base in organ pathophysiology and cell biology, as well as preclinical in vitro models and their application to drug development and discovery. Particular experience involving lung, bone marrow, intestine, blood brain barrier, and kidney, as well as human microbiome, would be advantageous. He or she will be responsible for application of human Organ Chip technology to mimic pathophysiology and develop novel therapeutics. Responsibilities include design of experimental procedures and protocols; management of interdisciplinary research teams; organization and oversight of experiments, and sample preparation/analysis. The successful candidate for this position will be capable of performing research andtraining team members (including technicians, graduate students, and postdoctoral fellows) in the use, design and implementation of in vitro studies, as well as key endpoint analyses. This will require a strong background in vitro cell based assays, requiring hands-on experience with primary cell culture, molecular and biochemical techniques, and discovery tools, such as CRISPR, phage display, or other molecular engineering approaches, in a research anddevelopment environment. The candidate will also work in collaborative efforts with other researchers and Faculty at the Institute across disciplines, Harvard University, and collaborating institutions. The chosen candidate for this position will contribute to the preparation of grants, protocols, presentations, and technical reports, and be a key point of contact with collaborators as well as funding institutions.School/Unit:Harvard Medical School EEO Statement:We are an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status, gender identity, sexual orientation, pregnancy and pregnancy-related conditions, or any other characteristic protected by law.