Tissue Bank Technician - Advanced Therapies Facility - 54154 - Band 400

Jul 04, 2019
Jul 17, 2019
Contract Type
Full Time
Job Type
Position Details

Advanced Therapies Facility, College of Medical and Dental Sciences

Starting salary is normally in the range £19,581 to £20,939. With potential progression once in post to £25,509 a year.

Full time

Fixed term contract 12 months

Closing date: 16 July 2019

Job summary
The main role of the post holder is delivery of the core services provided by the Human Biomaterials Resource Centre (HBRC). The HBRC is an HTA-licensed human sample biorepository and resides within the Advanced Therapies Facility (ATF). The ATF also houses both gene and cellular therapy manufacturing suites and is a quality controlled environment regulated by both the MHRA and the HTA.

The post holder will undertake the procurement and processing of appropriately consented quality assured and annotated biomaterials from patients in a wide range of disease settings for release or storage for biomedical research. In addition he/she will be delivering sample analytical and hosting services including samples collected from patients on clinical trials. They may be responsible for the oversight and delivery of all services associated with specific individual projects or collections.

The HBRC has developed into a key facility helping to deliver translational research programmes which are central to the College research strategy. The post is varied, requires a strong sense of initiative, the ability to work under time pressures, and also knowledge of the regulations, legislation and governance arrangements applicable to clinical research which uses human tissues and clinical trial samples. The post holder will interact with senior academic, clinical and surgical staff, and often with patients, therefore effective communication and strong interpersonal skills are essential.

Main duties

It is a requirement for both HTA and GCP compliance that all procedures within the HBRC are carried out according to strict Standard Operating Procedures (SOPs) which comply with all current regulations, legislation and governance arrangements surrounding the research use of human tissues and handling of clinical trial samples, and with Health and Safety regulations.

• To undertake the procurement of consented human biomaterials and subsequent processing, release or storage. This will involve the retrieval of fixed or fresh tissue samples from operating theatres or cellular pathology departments around the West Midlands, and the collection of blood samples and other body fluids from various hospital settings and subsequent processing. It will also involve the packing and dispatch of samples being released to biomedical researchers at external institutions. The post holder will be involved in the identification and recruitment of appropriate patients as well as control subjects from a number of NHS Trusts around the West Midlands, and will be responsible for the oversight and delivery of specific individual projects or collections. This will involve interaction with patients, clinicians, surgeons and researchers. The post holder will also be responsible for obtaining informed consent on an occasional basis.
• To contribute to delivery of the HBRC processing and analytical services e.g. tissue processing, sectioning, staining, microarray construction, cell and tissue culture, immunohistochemistry and nucleic acid extraction. This requires a wide range of advanced technical skills and will involve regular interaction with basic and clinical researchers and cellular pathology staff. He/she will be expected to advise on sample processing and analytical protocols and so be involved with study design, as well as analysis and interpretation of research data. They may be responsible for the oversight and delivery of all services associated with specific individual projects or collections. Attendance at relevant workshops and user/network groups will be encouraged to enhance knowledge, and to advance the technical capabilities of the HBRC service.
• Management of clinical trial samples received by the HBRC. This involves processing and storing samples according to clinical trial study protocols and associated SOPs. The post holder will be required to work closely with clinical trial co-ordinators and data managers (often multi-centre) to ensure that smooth processes are developed at set up, to co-ordinate the safe delivery of trial samples, and to ensure tasks are completed, often within tight deadlines. All procedures are required to be carried out in a manner compliant with Good Clinical Practice (GCP).
• Accurate completion of all necessary records and electronic sample tracking logs in all areas of activity so that sample traceability is maintained at all times. This is crucial for both HTA and GCP compliance.
• To assist with the collation of patient demographic and clinical data from medical records and clinical forms. This may involve searching NHS Trust clinical databases or paper health records, reading clinical reports and clinic letters and laboratory results to capture relevant project-specific information. To prepare accurate, complete and anonymised reports for researchers. This may also involves identifying and resolving any missing or incomplete data.
• To be responsible for basic housekeeping matters within the facility laboratories including monitoring and maintenance of equipment within the ATF.
• To contribute to the Quality Management System within the HBRC. Review of SOPs, risk assessments and COSHH assessments. To contribute to internal and external audit procedures, and to regulatory inspections.
• Any other duties within the ATF commensurate with the grade and skill base of the post holder as directed by the Director of the Facility and/or Operations Manager (Infrastructure).

Required Knowledge, Skills, Qualifications, Experience
• BTEC or BSc in a biological subject or equivalent relevant experience.
• Experience of handling human samples, blood and tissue processing (histology, cell culture, nucleic acid extraction) and analytical techniques (e.g. immunohistochemistry).
• Knowledge of the regulations, legislation and governance arrangements applicable to clinical research which uses human tissues, clinical data and clinical trial samples e.g. Human Tissue Act 2004, laboratory GCP, Research Governance Framework, Data Protection Act, and an understanding of working within the NHS environment.
• Well-developed working knowledge of data management and information systems e.g. sample logging software, clinical databases.
• Familiar with health and safety requirements/policies relating to biological, chemical, liquefied gases and manual handling.
• Must demonstrate a critical and intelligent attention to detail, high standards of accuracy.
• Ability to work independently, but also an aptitude for providing effective support for others and where necessary cover other areas of ATF work; a team player.
• Ability to prioritise tasks in order to ensure continuity of service in a time-pressured environment, and to resolve problems in their own area.
• Willingness and aptitude for learning and applying new skills, and to take responsibility of a particular area which will involve training other staff members.
• Must demonstrate effective communication and inter-personal skills and an ability to deal with colleagues and external stakeholders with tact and courtesy.
• Positive service attitude and ability/willingness to work outside of normal hours occasionally.

Informal enquires to Wendy Thomas. w.a.thomas@bham.ac.uk