Research Technician - Immunology and Immunotherapy - 81892 - Band 400

Location
Birmingham
Salary
Competitive
Posted
Aug 14, 2019
Closes
Aug 15, 2019
Ref
190002D9
Contract Type
Full Time
Job Type
Technican
Position Details

Institute of Immunology and Immunotherapy

University of Birmingham, Edgbaston, Birmingham

Full time starting salary is normally in the range £19,581 to £20,939. With potential progression once in post to £25,509 a year

Band 400

Full time/Fixed term for 15 Months

Closing Date: 14th August 2019

Job Purpose

The post holder will be based in the group of Professor Paul Moss in the Institute of Immunology and Immunotherapy; working on a portfolio of research projects funded from a variety of sources including MRC, CRUK, NIHR and Bloodwise. This post will entail working closely with scientists and clinicians to support high quality research. The post-holder will assist in research involving the roll of cellular immunity in clinical outcomes using patient samples obtained from the Queen Elizabeth Hospital, Birmingham.

Main duties

RESEARCH - 75%

• Preparation of blood mononuclear cells from human whole blood samples and extraction of tissue infiltrating lymphocytes.

• Isolation of T cells, NK cells and other cell leukocyte subsets as required from peripheral blood mononuclear cells and tissue

• Identification, characterisation and isolation of antigen-specific T cells

• Conducting multi-colour flow cytometry (surface, intracellular and intranuclear), running compensation matrices and basic maintenance of the flow cytometer.

• Preparation of samples for running on CyTOF and subsequent analysis of the results.

• Performance of immunological assays including cytotoxicity assays

• DNA extraction and PCR

• Keeping accurate records of all experiments, evaluating and interpreting results. Modifying experiments and suggesting new experimental approaches as appropriate.

• Keeping accurate records of patient samples

HEALTH AND SAFETY/ENVIRONMENTAL ISSUES - 10%

• Encouraging staff and students, working within the area of responsibility, to comply with all basic University / College Health & Safety policies. This may include compliance in the following areas; COSHH, genetically modified organisms (GMOs), human tissue, biological assessments, radioactive materials and schedule 5 toxins etc. Confirming all required assessments are in place, approved and up to date.

• Maintaining records both paper and computer based as appropriate.

• Carrying out regular maintenance processes such as flushing eye wash stations as appropriate and ensuring records are maintained.

• Reporting any breaches or non-compliance with H&S procedures to the PI, Technical Manager, Laboratory Manager or College Safety Adviser.

• Upholding the correct waste disposal stream as governed by College and local policy for laboratory, recycled and general waste

• Adopt a proactive attitude to assisting with and implementing carbon reduction and energy saving measures

GENERAL ADMINISTRATION AND ORGANISATION - 8%

The post holder will assist with the daily administration and organisation of the work area. These duties include:

• Maintaining stocks of consumables, if necessary, creating purchase order requisitions for the College finance office or via web based ordering system

• Receipt and correct storage of consumables and chemical reagents.

• Ensuring that the facilities are maintained in a clean, functional and safe condition, reporting any problems through the appropriate channels.

• Ensuring the best use of equipment through booking systems, if appropriate

• Reporting any problems with equipment or services to the line manager as appropriate.

• Any other duties commensurate with the grade and skill base of the post holder as directed by either the Principle investigator for research based activities or the Technical Managers for non-research based activities

OTHER DUTIES - 7%

• In collaboration with the Laboratory Manager or supervisor the post holder will take an active role in the training and mentoring process for junior or newly appointed staff/students

• To actively engage in the Personal Development Process

• To contribute at a level appropriate with the grade, to internal and external audit procedures, and to regulatory inspections.

• Assist Technical Managers and/or Laboratory Managers in identifying and tracking items held on the University asset register.

Person Specification

• Degree or equivalent professional qualification in an appropriate subject

• GCSE (A*- C) or equivalent in mathematics

• Proven practical knowledge of technical and scientific methods stated above and Good Laboratory Practice gained through experience and formal qualification

• Experience of similar laboratory-based work essential

• Experience of GCP, GCLP and clinical trial work would be an advantage

• Ability to liaise with research and clinical staff essential

• Ability to organise and manage own work load and demonstrate flexibility in terms of work practices/requirements

• Ability to work under minimal supervision but function as part of a team

• Knowledge of current relevant H&S policies

• Proficiency in commonly used software packages including flow cytometry analysis software

• Proficiency in managing electronic sample records and databases

For informal inquiries please contact Professor Paul Moss, p.moss@bham.ac.uk

Further particulars can be found on the link below

http://www.download.bham.ac.uk/vacancies/jd/MDSFPs.pdf

We value diversity at The University of Birmingham and welcome applications from all sections of the community'