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Acute arboviral infections in Guinea, West Africa, 2006.

by Michael J Carter, Kate R Emary, Catherine E Moore, Christopher M Parry, Mawlouth Diallo, Yamar Ba, Amadou A Sall, Ousmane M Diop, Jacques A Ndione, Mireille Mondo, Lang Girault, Christian Mathiot, Emily S Jentes, Jaimie Robinson, Barbara W Johnson, Ibrahima Conde, Yosse Sakouvougui, Jennifer Iverson, Shanna Beecher, M Alpha Bah, Fousseny Diakite, Mamadi Coulibaly, Daniel G Bausch, Juliet Bryan, Marycelin Baba, Christopher H Logue, Bamidele Oderinde, Hauwa Abdulmaleek, Joshua Williams, James Lewis, Thomas R Laws, Roger Hewson, Alessandro Marcello, D A Pierlanfranco, Laura J Sutherland, Ayla A Cash, Yan-jang Scott Huang, Rosemary C Sang, Indu Malhotra, Ann M Moormann, Charles H Christopher L King, Scott C Weaver, Charles H Christopher L King, A Desiree Labeaud, E Schwartz, E Meltzer, M Mendelson, A Tooke, F Steiner, P Gautret, Meng Ling Moi, Boris A M Pastorino, Patrick Gravier, Christophe N Peyrefitte, Olivier L Merle, Isabelle Moltini, Emilie Coppin, Fabienne Tock, William Daries, Hugues J Tolou, Marc Grandadam, Patrick M Bossuyt, Johannes B Reitsma, David E Bruns, Constantine A Gatsonis, Paul P Glasziou, Les M Irwig, Jeroen G Lijmer, David Moher, Drummond Rennie, Henrica C W De Vet, A W Mwongula, L A Mwamburi, M Matilu, D N Siamba, F W Wanyama, Veerle Msimang, Jacqueline Weyer, Chantel Roux, Pat Leman, Alan Kemp, Janusz Paweska, Rosanna W Peeling, Mark H Kuniholm, Nathan D Wolfe, Claire Y Huang, Ubald Tamoufe, New Haven, John a Crump, Anne B Morrissey, William L Nicholson, Robert F Massung, Robyn a Stoddard, Renee L Galloway, Eng Eong Ooi, Venance P Maro, Wilbrod Saganda, Grace D Kinabo, Charles Muiruri, John a Bartlett, Manuel R Pinto, L Franco, A Di Caro, F Carletti, O Vapalahti, C Renaudat, H Zeller, A Tenorio, Medical Sciences, Janet Awino Awando, Juliette Rose Ongus, Collins Ouma, Matilu Mwau, Monira Pervin, Shahina Tabassum, Bijon Kumar Sil, Md Nazrul Islam show all authors
The American journal of tropical medicine and hygiene ()
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Abstract

Acute febrile illnesses comprise the majority of the human disease burden in sub-Saharan Africa. We hypothesized that arboviruses comprised a considerable proportion of undiagnosed febrile illnesses in Guinea and sought to determine the frequency of arboviral disease in two hospitals there. Using a standard case definition, 47 suspected cases were detected in approximately 4 months. Immunoglobulin M antibody capture enzyme-linked immunosorbent assays and plaque-reduction neutralization assays revealed that 63% (30/47) of patients were infected with arboviruses, including 11 West Nile, 2 yellow fever, 1 dengue, 8 chikungunya, and 5 Tahyna infections. Except for yellow fever, these are the first reported cases of human disease from these viruses in Guinea and the first reported cases of symptomatic Tahyna infection in Africa. These results strongly suggest that arboviruses circulate and are common causes of disease in Guinea. Improving surveillance and laboratory capacity for arbovirus diagnoses will be integral to understanding the burden posed by these agents in the region.

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