Skip to content

Asymmetric synthesis of bicyclic intermediates of natural product chemistry

by Zoltan G. Hajos, David R. Parrish
The Journal of Organic Chemistry ()
Get full text at journal


The chemotype of a microbial or plant species has traditionally been defined as its profile of natural products, and the genotype has been defined as its genetic constitution or DNA sequence. The purpose of this perspective is to discuss applications of DNA genotyping, particularly by polymerase chain reaction (PCR)-amplification methods, to predicting natural product chemotypes of fungi and plants of importance in food and agriculture. Development of PCR genotyping for predicting chemotypes will require collaboration between molecular biologists and natural product chemists, as well as community standards for reporting data. PCR genotyping should be validated by chemical analysis of individuals that represent the allelic diversity of the target gene in the population. To avoid misinterpretation, it is critical to differentiate data obtained by genotyping from data obtained by chemical analysis. The obvious and appropriate solution is to retain the established meanings of genotype and chemotype, both of which have been in use for half a century in the fields of genetics and natural product chemistry.

Cite this document (BETA)

Readership Statistics

225 Readers on Mendeley
by Discipline
96% Chemistry
1% Agricultural and Biological Sciences
1% Materials Science
by Academic Status
36% Student > Ph. D. Student
18% Student > Master
17% Student > Bachelor
by Country
4% Germany
1% United Kingdom
1% Switzerland

Sign up today - FREE

Mendeley saves you time finding and organizing research. Learn more

  • All your research in one place
  • Add and import papers easily
  • Access it anywhere, anytime

Start using Mendeley in seconds!

Sign up & Download

Already have an account? Sign in