Biocomputing based on particle disassembly

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Abstract

Nanoparticles with biocomputing capabilities could potentially be used to create sophisticated robotic devices with a variety of biomedical applications, including intelligent sensors and theranostic agents. DNA/RNA-based computing techniques have already been developed that can offer a complete set of Boolean logic functions and have been used, for example, to analyse cells and deliver molecular payloads. However, the computing potential of particle-based systems remains relatively unexplored. Here, we show that almost any type of nanoparticle or microparticle can be transformed into autonomous biocomputing structures that are capable of implementing a functionally complete set of Boolean logic gates (YES, NOT, AND and OR) and binding to a target as result of a computation. The logic-gating functionality is incorporated into self-assembled particle/biomolecule interfaces (demonstrated here with proteins) and the logic gating is achieved through input-induced disassembly of the structures. To illustrate the capabilities of the approach, we show that the structures can be used for logic-gated cell targeting and advanced immunoassays. © 2014 Macmillan Publishers Limited. All rights reserved.

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Nikitin, M. P., Shipunova, V. O., Deyev, S. M., & Nikitin, P. I. (2014). Biocomputing based on particle disassembly. Nature Nanotechnology, 9(9), 716–722. https://doi.org/10.1038/nnano.2014.156

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