Clinicopathological features and treatment outcomes of primary laryngeal lymphomas in saudi population

Abstract

Background: Primary laryngeal lymphomas (PLLs) are rare and account for 1% -3% of all laryngeal neoplasms. Our aim was to describe the symptomology, diagnosis, histological variants and treatment outcomes of PLL in Saudi population. Materials and methods: Retrospective review of medical records of patients with laryngeal neoplasms, who were treated in our center in the period from July 2005 to December 2012, was performed. Demographic, radiologic and histopathological features and treatment outcomes were collected. Results: Among 57 records of patients with laryngeal carcinoma, two (3.51%) patients were diagnosed with PLLs. The frequent clinical presentation was hoarseness of voice. One (50%) patient hadmarginal zone B-cell mucosa-associated lymphoid tissue (MALT) lymphomas and other (50%) patient had T- Cell lymphoma (TCL). Both patients were treated with involved field radiotherapy 30-36 Gy in 15-18 fractions using RapidArc intensity modulated radiation therapy (IMRT). Median follow up was 12 months (6-14) with overall survival and disease free survival rates of 100% and 100%. Conclusion: PLLs are uncommon but with better outcomes than other sites lymphomas. Efforts are required for incorporation of immunohistochemical methodsto reach proper diagnosis and multimodality approach to improve the diagnosis and treatment outcomes.