Transcriptional regulation of circadian rhythms in mammals involves a negative-feedback loop whereby a CLOCK-BMAL1 complex activates transcription of the genes encoding the proteins PER1 (Period 1), PER2, CRY1 (Cryptochrome 1) and CRY2, which feed back to inhibit the activity of CLOCK-BMAL1. It is becoming evident that chromatin remodeling has a crucial role in the transcriptional regulation of genes governing circadian rhythms. This is highlighted in a recent report that shows that CLOCK has histone acetyltransferase activity, thus, demonstrating that molecular components of the biological clock can themselves catalyze chromatin modifications. © 2006 Elsevier Ltd. All rights reserved.
CITATION STYLE
Belden, W. J., Loros, J. J., & Dunlap, J. C. (2006, November). CLOCK leaves its mark on histones. Trends in Biochemical Sciences. https://doi.org/10.1016/j.tibs.2006.09.009
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