Skip to content

Cognitive screening for silent cerebral infarction in children with sickle cell disease

by D A White, A Moinuddin, R C McKinstry, M Noetzel, M Armstrong, M DeBaun
J Pediatr Hematol Oncol ()
Get full text at journal

Abstract

Silent cerebral infarctions have been shown to cause major morbidity in children with sickle cell disease, suggesting that silent infarctions are not as "silent" as once thought. The current definition of silent infarction includes signal changes on magnetic resonance imaging, the absence of overt abnormalities on neurologic examination, and no history of focal neurologic event. Using a decision tree algorithm, we identified a cognitive profile distinguishing children with (n=16) and without (n=49) silent infarctions. The best model combined learning slope from the California Verbal Learning Test-Children's Version and Block Design from the Wechsler Abbreviated Scale of Intelligence. Accuracy was 75%, with 75% sensitivity and 76% specificity. Administration of a brief cognitive battery may be the most feasible approach to screen for silent infarctions in children with sickle cell disease.

Cite this document (BETA)

Readership Statistics

4 Readers on Mendeley
by Discipline
 
100% Medicine and Dentistry
by Academic Status
 
25% Student > Master
 
25% Student > Ph. D. Student
 
25% Professor
by Country
 
25% Nigeria

Sign up today - FREE

Mendeley saves you time finding and organizing research. Learn more

  • All your research in one place
  • Add and import papers easily
  • Access it anywhere, anytime

Start using Mendeley in seconds!

Sign up & Download

Already have an account? Sign in