Comparative in vitro dissolution studies of rectal pharmaceutical products using the basket, the paddle and the flow through methods

Abstract

The purpose of our work was the studying of the in vitro dissolution behavior of suppositories containing piroxicam as active ingredient with the Flow-through method comparing the results with the ones obtained by the conventional stirred vessel-USP Paddle and Basket methods. The results indicate that the Flow-through method seems to be useful for studying the dissolution process of suppositories containing piroxicam giving reproducible dissolution data. The Flow-through cell method gives faster in vitro dissolution rates for piroxicam than those with the USP Paddle method, probably caused by steeper concentration gradient at the vicinity of the suppositories as well as better ability to uniformly wet them. The USP Basket method was found to give substantially slower dissolution rates than the other two methods.