Comparing whole genomes using DNA microarrays
- ISSN: 1471-0064 (Electronic) 1471-0056 (Linking)
- ISBN: 1471-0064 (Electronic)\r1471-0056 (Linking)
- DOI: nrg2335 [pii] 10.1038/nrg2335
- PubMed: 18347592
The rapid accumulation of complete genomic sequences offers the opportunity to carry out an analysis of inter- and intra-individual genome variation within a species on a routine basis. Sequencing whole genomes requires resources that are currently beyond those of a single laboratory and therefore it is not a practical approach for resequencing hundreds of individual genomes. DNA microarrays present an alternative way to study differences between closely related genomes. Advances in microarray-based approaches have enabled the main forms of genomic variation (amplifications, deletions, insertions, rearrangements and base-pair changes) to be detected using techniques that are readily performed in individual laboratories using simple experimental approaches.