Background: The literature contains evidence that Roux-en-Y gastric bypass (RYGB) surgery has an effect in humans on taste and preference for carbohydrate-rich foods. This study tested the hypothesis that RYGB affects sweet taste behavior using a rat model. Methods: Male Sprague-Dawley rats underwent either RYGB or sham surgery. Then 4 weeks after surgery, the rats were given taste-salient, brief-access lick tests with a series of sucrose concentrations. Results: The RYGB rats, but not the sham rats, lost weight over the 5-week postoperative period. The RYGB rats showed a significant decrease in mean licks for the highest concentration of sucrose (0.25-1.0 mol/l) but not for the low concentrations of sucrose or water. Conclusions: The findings showed that RYGB surgery affected sweet taste behavior in rats, with postsurgical rats having lower sensitivity or avidity for sucrose than sham-treated control rats. This finding is similar to human reports that sweet taste and preferences for high-caloric foods are altered after bypass surgery. © 2010 Springer Science+Business Media, LLC.
CITATION STYLE
Tichansky, D. S., Rebecca Glatt, A., Madan, A. K., Harper, J., Tokita, K., & Boughter, J. D. (2011). Decrease in sweet taste in rats after gastric bypass surgery. Surgical Endoscopy, 25(4), 1176–1181. https://doi.org/10.1007/s00464-010-1335-0
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