Enantioselective Mannich-type reaction catalyzed by a chiral Brønsted acid derived from TADDOL

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Abstract

A novel cyclic dialkyl phosphate was synthesized starting from (+)-diethyl tartrate. Its catalytic activity as a chiral Brønsted acid has been examined in the Mannich-type reaction of a ketene silyl acetal with aldimines as a model reaction. The corresponding β-amino acid esters were obtained with high enantioselectivity. © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.

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Akiyama, T., Saitoh, Y., Morita, H., & Fuchibe, K. (2005). Enantioselective Mannich-type reaction catalyzed by a chiral Brønsted acid derived from TADDOL. Advanced Synthesis and Catalysis, 347(11–13), 1523–1526. https://doi.org/10.1002/adsc.200505167

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