F-18-FDG uptake in tuberculosis
Two patients are described who showed abnormal fluorine-18\nfiuorodeoxyglucose (F-18 FDG) uptake that was due to benign disease,\nspecifically tuberculous lymphadenitis and pneumonitis. The first\npatient had ulceration and oozing of the left nipple that was related to\nPaget's disease. An F-18 FDG PET, whole-body scan, which was performed\nfor staging, showed no breast uptake. However, there was intense\nmultifocal uptake in mediastinal, supraclavicular, and para-aortic areas\nthat was confirmed radiologically to represent widespread\nlymphadenopathy. Pathologic examination of a mediastinal lymph node\nshowed active tuberculosis. The second patient showed intense focal F-18\nFDG uptake in mediastinal and supraclavicular areas and para-aortic\nlymphadenopathy due to non-Hodgkin's lymphoma. In addition, there was\nabnormal F-18 FDG lung uptake that revealed the presence of acid-fast\nbacilli on bronchial ravage. Intense focal F-18 FDG uptake in widespread\nlymphadenopathy or in the lung could be caused by infectious diseases\nsuch as tuberculosis. This possibility should be considered when\nwhole-body scans of patients with cancer are interpreted, especially in\nthose with a high incidence of infectious disease.