Gaining more flexibility in Cox proportional hazards regression models with cubic spline functions
- ISSN: 01692607
- ISBN: 0169-2607 (Print)\r0169-2607 (Linking)
- DOI: 10.1016/S0169-2607(97)00043-6
- PubMed: 9421665
The Cox proportional hazards model is the most popular model for the analysis of survival data. The use of cubic spline functions allows investigation of non-linear effects of continuous covariates and flexible assessment of time-by-covariate interactions. Two main advantages are provided—no particular functional form has to be specified and standard computer software packages like SAS or BMDP can be used. A SAS macro which implements the method is presented.