Gene-environment interactions in psychiatry: Joining forces with neuroscience

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Abstract

Gene-environment interaction research in psychiatry is new, and is a natural ally of neuroscience. Mental disorders have known environmental causes, but there is heterogeneity in the response to each causal factor, which gene-environment findings attribute to genetic differences at the DNA sequence level. Such findings come from epidemiology, an ideal branch of science for showing that a gene-environment interactions exist in nature and affect a significant fraction of disease cases. The complementary discipline of epidemiology, experimental neuroscience, fuels gene-environment hypotheses and investigates underlying neural mechanisms. This article discusses opportunities and challenges in the collaboration between psychiatry, epidemiology and neuroscience in studying gene-environment interactions.

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Caspi, A., & Moffitt, T. E. (2006, July). Gene-environment interactions in psychiatry: Joining forces with neuroscience. Nature Reviews Neuroscience. https://doi.org/10.1038/nrn1925

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