The Hartman interferometer, a proprietary integrated optic sensor, provides a basis for a broad range of biomedical diagnostics, including antibody-based and gene probe-based assays. As with other evanescent-wave optical sensors, the interferometer measures the refractive index change resulting from biomolecular binding on a waveguide surface. The exciting promise of evanescent-wave sensors lies, in general, in their potential to be used as label-free, real-time transducers that can operate in a true mix- and-read fashion and provide fast, quantitative results. One of the major issues facing their development, however, is creating a simple, low-cost configuration for multianalyte testing. The Hartman interferometer addresses this challenge by relying on linearly polarized light and a planar wave- guide format, thereby avoiding the problems associated with circular polarization and channel waveguides. We report preliminary experiments that demonstrate the applicability of this sensor configuration to detection of a wide range of protein, nucleic acid, and pathogen analytes.
CITATION STYLE
Schneider, B. H., Edwards, J. G., & Hartman, N. F. (1997). Hartman interferometer: Versatile integrated optic sensor for label- free, real-time quantification of nucleic acids, proteins, and pathogens. In Clinical Chemistry (Vol. 43, pp. 1757–1763). American Association for Clinical Chemistry Inc. https://doi.org/10.1093/clinchem/43.9.1757
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