Human cancers express mutator phenotypes: origin, consequences and targeting.
- ISSN: 1474-175X
- ISBN: 1474-1768 (Electronic)\r1474-175X (Linking)
- DOI: 10.1038/nrc3063
- PubMed: 21593786
- arXiv: 15334406
Recent data on DNA sequencing of human tumours have established that cancer cells contain thousands of mutations. These data support the concept that cancer cells express a mutator phenotype. This Perspective considers the evidence supporting the mutator phenotype hypothesis, the origin and consequences of a mutator phenotype, the implications for personalized medicine and the feasibility of ablating tumours by error catastrophe.