TNFα is expressed in high amounts at the site of inflammation in ankylosing spondylitis, which provided the basis to initiate treatment studies with TNF-blocking agents. We could show that the immunological effects of infliximab and etanercept differ in patients with AS, although the clinical effect was similarly good. While infliximab induced a downregulation of the production of the T-helper 1-cytokines IFNγ and TNFα, etanercept treatment triggered rather an upregulation of these cytokines secreted by T cells after in vitro stimulation.
CITATION STYLE
Zou, J. X., Braun, J., & Sieper, J. (2002). Immunological basis for the use of TNFα-blocking agents in ankylosing spondylitis and immunological changes during treatment. Clinical and Experimental Rheumatology, 20(6 SUPPL. 28).
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