Long-Range 1H-15N Heteronuclear Shift Correlation

Abstract

The investigation of long-range 1H-15N heteronuclear shift correlation NMR experiments has gone from its inception in 1995 to a robust area of research with numerous studies now reported annually. The area has been reviewed twice, covering the literature through about mid-2000. The present report covers the period from where this author's previous review stopped in late-1999 through the present. New long-range heteronuclear shift correlation methods that are applicable to long-range 1H-15N 2D heteronuclear shift correlation are discussed followed by a discussion of the impact of long-range 1H-15N data on Computer-Assisted Structure Elucidation methods and then a review of the applications of these techniques reported in the literature. © 2005 Elsevier Ltd. All rights reserved.