[Mitochondria and oocyte maturation].

by J Steffann, C Fallet
Journal de gynécologie, obstétrique et biologie de la reproduction ()
Get full text at journal

Abstract

Mitochondria play a central role in cellular energy metabolism. Mitochondrial genome (mtDNA) is specific with a maternal transmission. Defects of mtDNA, both quantitative (depletion) but also qualitative (mutation) were observed in patients with reproductive disorders, suggesting that a mitochondrial deficit could cause a failure of oocyte maturation. In our experience, some mtDNA point mutations would be subject to negative selection during female gametogenesis, with a threshold rate depending on the mutation. Below this threshold, the presence of mtDNA mutations would not impact oocyte maturation nor early embryonic development, as evidenced by the large number of oocytes and embryos carrying high mutation rates in our series.

Cite this document (BETA)

Readership Statistics

12 Readers on Mendeley
by Discipline
 
83% Biological Sciences
 
8% Environmental Sciences
 
8% Medicine
by Academic Status
 
33% Student (Bachelor)
 
25% Ph.D. Student
 
17% Student (Master)

Sign up today - FREE

Mendeley saves you time finding and organizing research. Learn more

  • All your research in one place
  • Add and import papers easily
  • Access it anywhere, anytime

Start using Mendeley in seconds!

Sign up & Download

Already have an account? Sign in