This article reviews the current and most neurologic uses of botulinum neurotoxin type A (BoNT-A), beginning with relevant historical data, neurochemical mechanism at the neuromuscular junction. Current commercial preparations of BoNT-A are reviewed, as are immunologic issues relating to secondary failure of BoNT-A therapy. Clinical uses are summarized with an emphasis on controlled clinical trials (as appropriate), including facial movement disorders, focal neck and limb dystonias, spasticity, hypersecretory syndromes, and pain. © 2007 Dove Medical Press Limited. All rights reserved.
CITATION STYLE
Ney, J. P., & Joseph, K. R. (2007). Neurologic uses of botulinum neurotoxin type A. Neuropsychiatric Disease and Treatment. DOVE Medical Press Ltd. https://doi.org/10.2147/ndt.s1612
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