Late organ toxicity from therapeutic radiation is a function of many confounding variables. The total dose delivered to the organ and the volumes of organ exposed to a given dose of radiation are 2 important variables that can be used to predict the risk of late toxicity. Three-dimensional radiation planning enables accurate calculation of the volume of tissue exposed to a given dose of radiation, graphically depicted as a dose-volume histogram. Dose metrics obtained from this 3-dimensional dataset can be used as a quantitative measure to predict late toxicity. This review summarizes the published clinical data on the risk of late toxicity as a function of quantitative dose metrics and attempts to offer suggested dose constraints for radiation treatment planning. © 2007 Elsevier Inc. All rights reserved.
CITATION STYLE
Milano, M. T., Constine, L. S., & Okunieff, P. (2007). Normal Tissue Tolerance Dose Metrics for Radiation Therapy of Major Organs. Seminars in Radiation Oncology, 17(2), 131–140. https://doi.org/10.1016/j.semradonc.2006.11.009
Mendeley helps you to discover research relevant for your work.