Skip to content

The Polycomb complex PRC2 and its mark in life.

by Raphaël Margueron, Danny Reinberg
Nature ()
Get full text at journal


Polycomb group proteins maintain the gene-expression pattern of different cells that is set during early development by regulating chromatin structure. In mammals, two main Polycomb group complexes exist - Polycomb repressive complex 1 (PRC1) and 2 (PRC2). PRC1 compacts chromatin and catalyses the monoubiquitylation of histone H2A. PRC2 also contributes to chromatin compaction, and catalyses the methylation of histone H3 at lysine 27. PRC2 is involved in various biological processes, including differentiation, maintaining cell identity and proliferation, and stem-cell plasticity. Recent studies of PRC2 have expanded our perspectives on its function and regulation, and uncovered a role for non-coding RNA in the recruitment of PRC2 to target genes.

Cite this document (BETA)

Readership Statistics

1188 Readers on Mendeley
by Discipline
74% Agricultural and Biological Sciences
13% Biochemistry, Genetics and Molecular Biology
7% Medicine and Dentistry
by Academic Status
33% Student > Ph. D. Student
26% Researcher
12% Student > Master
by Country
4% United States
2% United Kingdom
1% Germany

Sign up today - FREE

Mendeley saves you time finding and organizing research. Learn more

  • All your research in one place
  • Add and import papers easily
  • Access it anywhere, anytime

Start using Mendeley in seconds!

Sign up & Download

Already have an account? Sign in