Molecules associated with dead or dying cells can be detected by receptors on macrophages and dendritic cells. Signals from these receptors impact myeloid cell function and play a role in determining whether death is silent or proinflammatory, tolerogenic or immunogenic. Prominent among myeloid receptors detecting dead cells are C-type lectin receptors (CLRs). Signals from these receptors variably induce endocytosis of cell corpses, corpse degradation, retrieval of dead cell-associated antigens and/or modulation of immune responses. The sensing of tissue damage by myeloid CLRs complements detection of pathogens in immunity and represents an ancient response aimed at restoring tissue homeostasis. © 2012 Elsevier Ltd.
CITATION STYLE
Sancho, D., & Reis e Sousa, C. (2013, February). Sensing of cell death by myeloid C-type lectin receptors. Current Opinion in Immunology. https://doi.org/10.1016/j.coi.2012.12.007
Mendeley helps you to discover research relevant for your work.