The stem extract of Tephrosia purpurea showed antiplasmodial activity against the D6 (chloroquine-sensitive) and W2 (chloroquine-resistant) strains of Plasmodium falciparum with IC50 values of 10.47 ± 2.22 μg/ml and 12.06 ± 2.54 μg/ml, respectively. A new prenylated flavone, named terpurinflavone, along with the known compounds lanceolatin A, (-)-semiglabrin and lanceolatin B have been isolated from this extract. The new compound, terpurinflavone, showed the highest antiplasmodial activity with IC50 values of 3.12 ± 0.28 μM (D6) and 6.26 ± 2.66 μM (W2). The structures were determined on the basis of spectroscopic evidence. © 2011 Phytochemical Society of Europe.
CITATION STYLE
Juma, W. P., Akala, H. M., Eyase, F. L., Muiva, L. M., Heydenreich, M., Okalebo, F. A., … Yenesew, A. (2011). Terpurinflavone: An antiplasmodial flavone from the stem of Tephrosia Purpurea. Phytochemistry Letters, 4(2), 176–178. https://doi.org/10.1016/j.phytol.2011.02.010
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