Trends in pathogens colonising the respiratory tract of adult patients with cystic fibrosis, 1985-2005

Abstract

Introduction: The treatment of patients with CF has continued to evolve. We hypothesised that sputum microbiology may have changed as a result of this. Method: Retrospective analysis of sputum microbiology from adult CF patients (1985 to 2005) using the Royal Brompton Hospital CF database. Results: Colonisation with Pseudomonas aeruginosa or Staphylococcus aureus between 1985 and 2005 remained stable (77 to 82%, p = 0.159; 54 to 47%, p = 0.108; respectively). Haemophilus influenzae (48 to 6%; p < 0.001), Aspergillus species (18 to 9%; p = 0.002) and Burkholderia cepacia complex (9 to 4%; p = 0.041) prevalence decreased. Stenotrophomonas maltophilia and MRSA increased (1 to 4%, p = 0.02; 1 to 6%, p = 0.002, respectively). Conclusion: P. aeruginosa colonisation has remained stable; there has been a decline in B. cepacia complex, H. influenzae and Aspergillus sp., and only a small increase in S. maltophilia and MRSA. Intensive antibiotic strategies have been employed, which, so far, have not resulted in clinically significant emergence of new pathogens. © 2009 European Cystic Fibrosis Society.