Trisoxazoline/Cu(II)-catalyzed asymmetric intramolecular Friedel-Crafts alkylation reaction of indoles

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Abstract

Intramolecular Friedel-Crafts alkylation reaction of indoles catalyzed by trisoxazoline/copper(II) is described. This annulation provides an easy access to polycyclic indole derivatives with up to 90% ee in up to 99% yield. © 2009 Elsevier Ltd. All rights reserved.

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Zhou, J. L., Ye, M. C., Sun, X. L., & Tang, Y. (2009). Trisoxazoline/Cu(II)-catalyzed asymmetric intramolecular Friedel-Crafts alkylation reaction of indoles. Tetrahedron, 65(34), 6877–6881. https://doi.org/10.1016/j.tet.2009.06.071

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