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Tyrosine and its potential use as a countermeasure to performance decrement in military Sustained Operations

by J. O. Owasoyo, D. F. Neri, J. G. Lamberth
Aviation Space and Environmental Medicine ()


Reviews the biochemistry and physiological role of the amino acid tyrosine in normal and stressful situations such as military sustained operations (SUSOPs), which consist of continuous work periods exceeding 12 hrs and involve sleep loss and fatigue. These, in turn, can lead to stress, anxiety, and performance decrement (PFD). Tyrosine, a precursor of norepinephrine, may be useful in counteracting stress-related PFD and mood deterioration in the following ways: Various forms of stress induce brain depletion of catecholamines, especially norepinephrine, in animals; brain norepinephrine levels are closely related to stress-induced PFD in animals; and tyrosine may minimize or reverse stress-induced PFD by increasing depleted brain norepinephrine levels. The types of PFDs expected in military SUSOPs and the role tyrosine might play in improving mood and performance are discussed. (PsycINFO Database Record (c) 2016 APA, all rights reserved)

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