It is unclear how an effective T cell repertoire is built from a limited array of T cell receptor (TCR) genes. In this issue of Immunity, Stadinski et al. (2011) demonstrate that TCR variable (V) α chains can indirectly affect Vβ-mediated recognition of the major histocompatibility complex (MHC) molecule. © 2011 Elsevier Inc.
Turner, S. J., & Rossjohn, J. (2011, November 23). αβ T cell receptors come out swinging. Immunity. https://doi.org/10.1016/j.immuni.2011.11.002