β-Defensin-2 protein is a serum biomarker for disease activity in psoriasis and reaches biologically relevant concentrations in lesional skin

120Citations
Citations of this article
81Readers
Mendeley users who have this article in their library.

Abstract

Previous studies have extensively documented antimicrobial and chemotactic activities of beta-defensins. Human beta-defensin-2 (hBD-2) is strongly expressed in lesional psoriatic epidermis, and recently we have shown that high beta-defensin genomic copy number is associated with psoriasis susceptibility. It is not known, however, if biologically and pathophysiologically relevant concentrations of hBD-2 protein are present in vivo, which could support an antimicrobial and proinflammatory role of beta-defensins in lesional psoriatic epidermis.

Cite

CITATION STYLE

APA

Jansen, P. A. M., Rodijk-Olthuis, D., Hollox, E. J., Kamsteeg, M., Tjabringa, G. S., de Jongh, G. J., … Schalkwijk, J. (2009). β-Defensin-2 protein is a serum biomarker for disease activity in psoriasis and reaches biologically relevant concentrations in lesional skin. PLoS ONE, 4(3). https://doi.org/10.1371/journal.pone.0004725

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free