Previous studies have extensively documented antimicrobial and chemotactic activities of beta-defensins. Human beta-defensin-2 (hBD-2) is strongly expressed in lesional psoriatic epidermis, and recently we have shown that high beta-defensin genomic copy number is associated with psoriasis susceptibility. It is not known, however, if biologically and pathophysiologically relevant concentrations of hBD-2 protein are present in vivo, which could support an antimicrobial and proinflammatory role of beta-defensins in lesional psoriatic epidermis.
Jansen, P. A. M., Rodijk-Olthuis, D., Hollox, E. J., Kamsteeg, M., Tjabringa, G. S., de Jongh, G. J., … Schalkwijk, J. (2009). β-Defensin-2 protein is a serum biomarker for disease activity in psoriasis and reaches biologically relevant concentrations in lesional skin. PLoS ONE, 4(3). https://doi.org/10.1371/journal.pone.0004725