Role of Nuclear Factor Erythroid 2-Related Factor 2 in Diabetic Nephropathy

17Citations
Citations of this article
22Readers
Mendeley users who have this article in their library.

Abstract

Diabetic nephropathy (DN) is manifested as increased urinary protein level, decreased glomerular filtration rate, and final renal dysfunction. DN is the leading cause of end-stage renal disease worldwide and causes a huge societal healthcare burden. Since satisfied treatments are still limited, exploring new strategies for the treatment of this disease is urgently needed. Oxidative stress takes part in the initiation and development of DN. In addition, nuclear factor erythroid 2-related factor 2 (Nrf2) plays a key role in the cellular response to oxidative stress. Thus, activation of Nrf2 seems to be a new choice for the treatment of DN. In current review, we discussed and summarized the therapeutic effects of Nrf2 activation on DN from both basic and clinical studies.

Cite

CITATION STYLE

APA

Cui, W., Min, X., Xu, X., Du, B., & Luo, P. (2017). Role of Nuclear Factor Erythroid 2-Related Factor 2 in Diabetic Nephropathy. Journal of Diabetes Research. Hindawi Limited. https://doi.org/10.1155/2017/3797802

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free