Background: Novel 3-dimensional echocardiography with speckle tracking imaging (3D-STE) may have advantages in assessing left ventricular (LV) volume through a cardiac cycle. The feasibility of 3D-STE may be affected by image quality and LV morphology. Methods and results: We studied 64 patients (38 men, age 55. ±. 12 years) who underwent cardiac magnetic resonance imaging (CMRI) and 3D-STE on the same day. LV end-diastolic volume (EDV) and end-systolic volume (ESV) were measured by both modalities. Imaging qualities were quantified in each of 6 LV segments by an imaging quality score (IQS) of 1-3, and scores were averaged (mean IQS) at end-diastole and end-systole. Compared to CMRI, 3D-STE showed a tendency to underestimate LV volume measurements, but not significantly (EDV: bias. = -18. ±. 37. ml; ESV: bias. = -10. ±. 34. ml), and measurements correlated well with those by CMRI (EDV: R= 0.80, ESV: R= 0.86, ejection fraction: R= 0.75, p<. 0.001). The absolute differences of LVEDV and ESV between 3D-STE and CMRI correlated significantly with mean IQS (LVEDV, R= -0.35, p= 0.005; LVESV, R= -0.30, p= 0.02). Based on the medium value of LVEDV by CMRI (127. ml), subjects were classified into the small (<127. ml) and large LVEDV ( 127. ml) groups. In the large LVEDV group, mean IQS significantly correlated with the absolute differences of LVEDV (mean IQS, r= -0.45, p= 0.01), despite no significant correlation in the small LVEDV group. Conclusion: 3D-STE could measure LV volume as well as CMRI, however, its accuracy depends on the quality of the acquired image and particularly on enlargement of the left ventricle. © 2013 Japanese College of Cardiology.
Kawamura, R., Seo, Y., Ishizu, T., Atsumi, A., Yamamoto, M., Machino-Ohtsuka, T., … Aonuma, K. (2014). Feasibility of left ventricular volume measurements by three-dimensional speckle tracking echocardiography depends on image quality and degree of left ventricular enlargement: Validation study with cardiac magnetic resonance imaging. Journal of Cardiology, 63(3), 230–238. https://doi.org/10.1016/j.jjcc.2013.08.010